New in vitro model for proarrhythmia safety screening IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts /
Introduction: Preclinical in vivo QT measurement as a proarrhythmia essay is expensive and not reliable enough. The aim of the present study was to develop a sensitive, cost-effective, Langendorff perfused guinea pig heart model for proarrhythmia safety screening. Methods: Low concentrations of dofe...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
80 |
| doi: | 10.1016/j.vascn.2016.04.005 |
| mtmt: | 3058849 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11928 |