Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy
Stratification models for the prediction of sudden cardiac death (SCD) are inappropriate in patients with hypertrophic cardiomyopathy (HCM). We investigated conventional electrocardiogram (ECG) repolarization parameters and the beat-to-beat short-term QT interval variability (QT-STV), a new paramete...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
93 No. 9 |
| doi: | 10.1139/cjpp-2014-0526 |
| mtmt: | 2937124 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11594 |
| LEADER | 02627nab a2200313 i 4500 | ||
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| 024 | 7 | |a 10.1139/cjpp-2014-0526 |2 doi | |
| 024 | 7 | |a 2937124 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Orosz Andrea | |
| 245 | 1 | 0 | |a Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy |h [elektronikus dokumentum] / |c Orosz Andrea |
| 260 | |c 2015 | ||
| 300 | |a 765-772 | ||
| 490 | 0 | |a CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY |v 93 No. 9 | |
| 520 | 3 | |a Stratification models for the prediction of sudden cardiac death (SCD) are inappropriate in patients with hypertrophic cardiomyopathy (HCM). We investigated conventional electrocardiogram (ECG) repolarization parameters and the beat-to-beat short-term QT interval variability (QT-STV), a new parameter of proarrhythmic risk, in 37 patients with HCM (21 males, average age 48 +/- 15 years). Resting ECGs were recorded for 5 min and the frequency corrected QT interval (QTc), QT dispersion (QTd), beat-to-beat short-term variability of QT interval (QT-STV), and the duration of terminal part of T waves (Tpeak-Tend) were calculated. While all repolarization parameters were significantly increased in patients with HCM compared with the controls (QTc, 488 +/- 61 vs. 434 +/- 23 ms, p < 0.0001; QT-STV, 4.5 +/- 2 vs. 3.2 +/- 1 ms, p = 0.0002; Tpeak-Tend duration, 107 +/- 27 vs. 91 +/- 10 ms, p = 0.0015; QTd, 47 +/- 17 vs. 34 +/- 9 ms, p = 0.0002), QT-STV had the highest relative increase (+41%). QT-STV also showed the best correlation with indices of left ventricular (LV) hypertrophy, i.e., maximal LV wall thickness normalized for body surface area (BSA; r = 0.461, p = 0.004) or LV mass (determined by cardiac magnetic resonance imaging) normalized for BSA (r = 0.455, p = 0.015). In summary, beat-to-beat QT-STV showed the most marked increase in patients with HCM and may represent a novel marker that merits further testing for increased SCD risk in HCM. | |
| 700 | 0 | 1 | |a Baczkó István |e aut |
| 700 | 0 | 1 | |a Nagy Viktória |e aut |
| 700 | 0 | 1 | |a Gavallér Edit Henriette |e aut |
| 700 | 0 | 1 | |a Csanády Miklós |e aut |
| 700 | 0 | 1 | |a Forster Tamás |e aut |
| 700 | 0 | 1 | |a Papp Gyula |e aut |
| 700 | 0 | 1 | |a Varró András |e aut |
| 700 | 0 | 1 | |a Lengyel Csaba Attila |e aut |
| 700 | 0 | 1 | |a Sepp Róbert |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11594/1/QT_STV_in_HCM_Orosz_et_al_CJPP_2015_u.pdf |z Dokumentum-elérés |