Regional differences in the neuronal expression of cyclooxygenase-2 (COX-2) in the newborn pig brain

Cycoxygene (COX-2 is the major costitutively expressed COX isoform in the newborn brain. COX-2 derived prostanoids and reactive oxygen species appear to play a major role in the mechanism of perinatal hypoxic-ischemic injury in the newborn piglet, an accepted animal model of the human term neonate....

Full description

Saved in:
Bibliographic Details
Main Authors: Oláh Orsolya
Németh István Balázs
Tóth-Szűki Valéria
Bari Ferenc
Domoki Ferenc
Format: Article
Published: 2012
Series:ACTA HISTOCHEMICA ET CYTOCHEMICA 45 No. 3
doi:10.1267/ahc.11056

mtmt:2027259
Online Access:http://publicatio.bibl.u-szeged.hu/11403
LEADER 02357nab a2200253 i 4500
001 publ11403
005 20200224124541.0
008 170522s2012 hu o 0|| zxx d
022 |a 0044-5991 
024 7 |a 10.1267/ahc.11056  |2 doi 
024 7 |a 2027259  |2 mtmt 
040 |a SZTE Publicatio Repozitórium  |b hun 
041 |a zxx 
100 1 |a Oláh Orsolya 
245 1 0 |a Regional differences in the neuronal expression of cyclooxygenase-2 (COX-2) in the newborn pig brain  |h [elektronikus dokumentum] /  |c  Oláh Orsolya 
260 |c 2012 
300 |a 187-192 
490 0 |a ACTA HISTOCHEMICA ET CYTOCHEMICA  |v 45 No. 3 
520 3 |a Cycoxygene (COX-2 is the major costitutively expressed COX isoform in the newborn brain. COX-2 derived prostanoids and reactive oxygen species appear to play a major role in the mechanism of perinatal hypoxic-ischemic injury in the newborn piglet, an accepted animal model of the human term neonate. The study aimed to quantitatively determine COX-2 immunopositive neurons in different brain regions in piglets under normoxic conditions (n=15), and 4 hours after 10 min asphyxia (n=11). Asphyxia did not induce significant changes in neuronal COX-2 expression of any studied brain areas. In contrast, there was a marked regional difference in all experimental groups. Thus, significant difference was observed between fronto-parietal and temporo-occipital regions: 59±4% and 67±3% versus 41±2%* and 31±3%* respectively (mean±SEM, data are pooled from all subjects, n=26, *p<0.05, vs. fronto-parietal region). In the hippocampus, COX-2 immunopositivity was rare (highest expression in CA1 region: 14±2%). The studied subcortical areas showed negligible COX-2 staining. Our findings suggest that asphyxia does not significantly alter the pattern of neuronal COX-2 expression in the early reventilation period. Furthermore, based on the striking differences observed in cortical neuronal COX-2 distribution, the contribution of COX-2 mediated neuronal injury after asphyxia may also show region-specific differences. © 2012 The Japan Society of Histochemistry and Cytochemistry. 
700 0 1 |a Németh István Balázs  |e aut 
700 0 2 |a Tóth-Szűki Valéria  |e aut 
700 0 2 |a Bari Ferenc  |e aut 
700 0 2 |a Domoki Ferenc  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/11403/1/Olah_Acta_Histochem_2012.pdf  |z Dokumentum-elérés