01534nab a2200253 i 4500 publ11099 20200211133823.0 170330s2015 hu o 0|| zxx d 0731-7085 10.1016/j.jpba.2014.09.020 doi 2776534 mtmt SZTE Publicatio Repozitórium hun zxx Langó Péter Analysis of the polymorph changes of a drug candidate [elektronikus dokumentum] / Langó Péter 2015 229-235 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 102 The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The VH-XRPD study showed that all 8 polymorphic forms of this material were stable in the interval 20-80 RH%. The VT-XRPD measurements indicated that all the polymorphs except Form II underwent changes in the range 30-200 degrees C. The stable form was Form II, though Form IVb had almost the same stability. The investigation demonstrated that VT-XRPD is a very useful in situ method for relative stability studies. Várkonyi E. aut Ulrich Joachim aut Révész Piroska aut Aigner Zoltán aut http://publicatio.bibl.u-szeged.hu/11099/1/Lang__JPBA_u.pdf Dokumentum-elérés