Surgical Repair of Mitral Valve Disease in Children Perioperative Changes in Respiratory Function /
OBJECTIVE: To assess the profile of changes in airway and respiratory tissue mechanics within a follow-up study performed in children with mitral valve disease, before and after surgical valve repair. DESIGN: Perioperative measurements in a prospective, consecutive cross-sectional study. SETTING: Un...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
30 No. 5 |
| doi: | 10.1053/j.jvca.2016.05.018 |
| mtmt: | 3130288 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11026 |
| LEADER | 03183nab a2200289 i 4500 | ||
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| 008 | 170314s2016 hu o 0|| zxx d | ||
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| 024 | 7 | |a 10.1053/j.jvca.2016.05.018 |2 doi | |
| 024 | 7 | |a 3130288 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Malaspinas Iliona | |
| 245 | 1 | 0 | |a Surgical Repair of Mitral Valve Disease in Children |h [elektronikus dokumentum] : |b Perioperative Changes in Respiratory Function / |c Malaspinas Iliona |
| 260 | |c 2016 | ||
| 300 | |a 1286-1295 | ||
| 490 | 0 | |a JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA |v 30 No. 5 | |
| 520 | 3 | |a OBJECTIVE: To assess the profile of changes in airway and respiratory tissue mechanics within a follow-up study performed in children with mitral valve disease, before and after surgical valve repair. DESIGN: Perioperative measurements in a prospective, consecutive cross-sectional study. SETTING: University hospital, tertiary care teaching hospital PARTICIPANTS: The study comprised 24 children with congenital or post-rheumatic mitral valve insufficiency. INTERVENTIONS: Input impedance of the respiratory system during spontaneous breathing was measured before and 5 days and 3 weeks after mitral valve surgery. In addition, airway and respiratory tissue mechanics and pulmonary arterial pressure were assessed with the patient under general anesthesia preoperatively and immediately postoperatively. Respiratory tissue elastance and changes in airway measurements were estimated from forced oscillatory impedance data by fitting an appropriate model. MEASUREMENT AND MAIN RESULTS: Relating airway and respiratory tissue mechanics to previously established reference values obtained in age-matched healthy control patients revealed abnormal respiratory function (135+/-6.2% and 148+/-13% in respiratory elastance and resistance, respectively; p<0.001). Improvement in the airway properties was observed immediately after surgery (-15.2+/-3.4%; p<0.005) and lasted for the study period (-19+/-4.1%; p<0.001). Respiratory tissue elastance, which correlated preoperatively to the diastolic pulmonary arterial pressure, decreased only 5 days postoperatively (-20.6+/-4.1%; p<0.005). However, there was no evidence of a clear, immediate effect of surgery on the tissue mechanical parameters measured intraoperatively despite a decrease in diastolic pulmonary pressure. CONCLUSIONS: Mitral valve disease in children leads to abnormal airway and respiratory tissue mechanics. Even though surgical repair of mitral insufficiency alleviates abnormal airway function, residual lung tissue stiffening may persist even weeks after the surgery, contributing to a sustained impairment in lung function. | |
| 700 | 0 | 1 | |a Peták Ferenc |e aut |
| 700 | 0 | 1 | |a Chok Lionel |e aut |
| 700 | 0 | 1 | |a Perrin Anne |e aut |
| 700 | 0 | 1 | |a Martin Anne-Laure |e aut |
| 700 | 0 | 1 | |a Beghetti Maurice |e aut |
| 700 | 0 | 1 | |a Habre Walid |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11026/1/JCVA_S_16_00009_u.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11026/7/Cardiothoracic_and_Vascular_Anesthesia_30_5.pdf |z Dokumentum-elérés |