Neocortical c-fos mRNA transcription in repeated, brief, acute seizures is c-fos a coincidence detector? /
The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4- aminopyridine. Electroencephalography in freely moving animals with implanted neocortical electrodes detected an average of 2.67 tonic-clonic convulsions within 1 h following the 4...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2005
|
| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
15 No. 3 |
| mtmt: | 1300387 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10887 |
| LEADER | 02075nab a2200301 i 4500 | ||
|---|---|---|---|
| 001 | publ10887 | ||
| 005 | 20190716142715.0 | ||
| 008 | 170303s2005 hu o 0|| angol d | ||
| 022 | |a 1107-3756 | ||
| 024 | 7 | |a 1300387 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Mihály András | |
| 245 | 1 | 0 | |a Neocortical c-fos mRNA transcription in repeated, brief, acute seizures |h [elektronikus dokumentum] : |b is c-fos a coincidence detector? / |c Mihály András |
| 260 | |c 2005 | ||
| 300 | |a 481-486 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE |v 15 No. 3 | |
| 520 | 3 | |a The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4- aminopyridine. Electroencephalography in freely moving animals with implanted neocortical electrodes detected an average of 2.67 tonic-clonic convulsions within 1 h following the 4-AP treatment. Tissue samples of the somatosensory neocortex were collected at 30 min, 1 h, 3 h, 5 h and 8 h following the treatment for PCR and immunohistochemistry. The c-fos mRNA displayed the first significant rise at 1 h, and remained significantly higher through 3 h. The number of c-fos protein immunoreactive cells was significantly elevated already at 30 min, peaked at 1 h, and declined by 5 h. We conclude that in repetitive, brief seizures, the first convulsion does not increase c-fos RNA transcription, whilst the second causes a long-lasting gene expression and a large increase of c-fos protein synthesis. The phenomenon may have implications in the pathogenesis of human and animal epilepsies. | |
| 700 | 0 | 1 | |a Borbély Sándor |e aut |
| 700 | 0 | 1 | |a Világi Ildikó |e aut |
| 700 | 0 | 1 | |a Détári László |e aut |
| 700 | 0 | 1 | |a Weiczner Roland |e aut |
| 700 | 0 | 1 | |a Zádor Zsolt |e aut |
| 700 | 0 | 2 | |a Krisztinné Péva Beáta |e aut |
| 700 | 0 | 2 | |a Bagosi Andrea |e aut |
| 700 | 0 | 2 | |a Kopniczky Zsolt |e aut |
| 700 | 0 | 2 | |a Zádor Ernő |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10887/1/2005_Mihaly_et_al._Int_J_Mol_Med_u.pdf |z Dokumentum-elérés |