Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents A confirmation study in a colon cancer MDR cell line /
Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment and as a continuation of our efforts to overcome this problem we report the evaluation of one cyclic selenoanhydride (1) and ten selenoesters (2-11) in MDR human colon adenocarcinom...
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| Dokumentumtípus: | Cikk |
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Pergamon Press
2017
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| Sorozat: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
27 No. 4 |
| doi: | 10.1016/j.bmcl.2017.01.033 |
| mtmt: | 3179770 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10711 |
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| 024 | 7 | |a 10.1016/j.bmcl.2017.01.033 |2 doi | |
| 024 | 7 | |a 3179770 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Gajdács Márió | |
| 245 | 1 | 0 | |a Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents |h [elektronikus dokumentum] : |b A confirmation study in a colon cancer MDR cell line / |c Gajdács Márió |
| 260 | |a Pergamon Press |c 2017 | ||
| 300 | |a 797-802 | ||
| 490 | 0 | |a BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |v 27 No. 4 | |
| 520 | 3 | |a Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment and as a continuation of our efforts to overcome this problem we report the evaluation of one cyclic selenoanhydride (1) and ten selenoesters (2-11) in MDR human colon adenocarcinoma Colo 320 cell line. The most potent derivatives (1, 9-11) inhibited the ABCB1 efflux pump much stronger than the reference compound verapamil. Particularly, the best one (9) was 4-fold more potent than verapamil at a 10-fold lower concentration. Furthermore, the evaluated derivatives exerted a potent and selective cytotoxic activity. In addition, they were strong apoptosis inducers as the four derivatives triggered apoptotic events in a 64-72% of the examined MDR Colo 320 human adenocarcinoma cells. | |
| 700 | 0 | 1 | |a Spengler Gabriella |e aut |
| 700 | 0 | 1 | |a Sanmartín Carmen |e aut |
| 700 | 0 | 1 | |a Marć Małgorzata Anna |e aut |
| 700 | 0 | 1 | |a Handzlik Jadwiga |e aut |
| 700 | 0 | 2 | |a Domínguez-Álvarez Enrique |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10711/1/3179770.pdf |z Dokumentum-elérés |