Nonenzymatic antioxidants of blood in multiple sclerosis
Free radical action has been suggested as a causal factor in multiple sclerosis. We investigated the plasma level of lipid peroxides expressed in terms of malone dialdehyde and changes in blood nonenzymatic antioxidants (glutathione, alpha-tocopherol, retinol, plasma sulfhydryl groups, and uric acid...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
Springer
1999
|
| Sorozat: | JOURNAL OF NEUROLOGY
246 No. 7 |
| doi: | 10.1007/s004150050399 |
| mtmt: | 1032254 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10535 |
| LEADER | 02074nab a2200265 i 4500 | ||
|---|---|---|---|
| 001 | publ10535 | ||
| 005 | 20221104095914.0 | ||
| 008 | 170214s1999 hu o 0|| zxx d | ||
| 022 | |a 0340-5354 | ||
| 024 | 7 | |a 10.1007/s004150050399 |2 doi | |
| 024 | 7 | |a 1032254 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Karg Eszter | |
| 245 | 1 | 0 | |a Nonenzymatic antioxidants of blood in multiple sclerosis |h [elektronikus dokumentum] / |c Karg Eszter |
| 260 | |a Springer |c 1999 | ||
| 300 | |a 533-539 | ||
| 490 | 0 | |a JOURNAL OF NEUROLOGY |v 246 No. 7 | |
| 520 | 3 | |a Free radical action has been suggested as a causal factor in multiple sclerosis. We investigated the plasma level of lipid peroxides expressed in terms of malone dialdehyde and changes in blood nonenzymatic antioxidants (glutathione, alpha-tocopherol, retinol, plasma sulfhydryl groups, and uric acid) in multiple sclerosis patients with exacerbation or in remission, including a group treated with beta-interferon. The malone dialdehyde level was increased by 38% (n.s.) during exacerbations. The blood concentration of oxidized glutathione was likewise elevated (P<0.05), while the ratio of plasma alpha-tocopherol to cholesterol plus triglyceride was decreased (P<0.001). These changes suggest increased free radical production and consumption of the scavenger molecules during the active phase of the disease. Blood reduced glutathione level was increased (P<0.01) during exacerbation and remission as well. The rise in this thiol is likely to be a compensatory mechanism defending the cells from further oxidant injuries. Beta-interferon increased plasma alpha-tocopherol levels (P<0.001) but not the lipid corrected alpha-tocopherol value. Other parameters were not influenced by the drug. | |
| 700 | 0 | 1 | |a Klivényi Péter |e aut |
| 700 | 0 | 1 | |a Németh Ilona |e aut |
| 700 | 0 | 1 | |a Bencsik Krisztina |e aut |
| 700 | 0 | 1 | |a Pintér Sándor |e aut |
| 700 | 0 | 1 | |a Vécsei László |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10535/1/Karg_E._Nonenzymatic_antioxidants_in_MS._u.pdf |z Dokumentum-elérés |