Multidrug Resistance Reversing Activity of Newly Developed Phenothiazines on P-glycoprotein (ABCB1)-related Resistance of Mouse T-Lymphoma Cells
BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity. MATERIALS AND METHODS: A series of new phenothiazine deriva...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2014
|
| Sorozat: | ANTICANCER RESEARCH
34 No. 4 |
| mtmt: | 2583773 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10441 |
| LEADER | 02055nab a2200265 i 4500 | ||
|---|---|---|---|
| 001 | publ10441 | ||
| 005 | 20190607154055.0 | ||
| 008 | 170206s2014 hu o 0|| zxx d | ||
| 022 | |a 0250-7005 | ||
| 024 | 7 | |a 2583773 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Spengler Gabriella | |
| 245 | 1 | 0 | |a Multidrug Resistance Reversing Activity of Newly Developed Phenothiazines on P-glycoprotein (ABCB1)-related Resistance of Mouse T-Lymphoma Cells |h [elektronikus dokumentum] / |c Spengler Gabriella |
| 260 | |c 2014 | ||
| 300 | |a 1737-1741 | ||
| 490 | 0 | |a ANTICANCER RESEARCH |v 34 No. 4 | |
| 520 | 3 | |a BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity. MATERIALS AND METHODS: A series of new phenothiazine derivatives was investigated regarding their ABCB1-modulating effect on multidrug resistant mouse T-lymphoma cells by rhodamine 123 accumulation assay and real-time ethidium bromide accumulation assay. RESULTS: The phenothiazine derivatives exhibited a potent anticancer effect on the parental cell line and on its multidrug-resistant mouse T-lymphoma subline overexpressing the ABCB1 transporter. The inhibition of the ABCB1 transporter in the presence of the newly-developed phenothiazines was greater than that for the known ABCB1 inhibitors thioridazine and verapamil. CONCLUSION: Based on the chemical structures and biological activity, compounds with bivalent sulfur atom in the phenothiazine ring demonstrated marked ABCB1-modulating effect, however, other derivatives with halogen or amide substitutions were ineffective. | |
| 700 | 0 | 1 | |a Takács Daniella |e aut |
| 700 | 0 | 1 | |a Horváth Ádám |e aut |
| 700 | 0 | 1 | |a Riedl Zsuzsanna |e aut |
| 700 | 0 | 1 | |a Hajós György |e aut |
| 700 | 0 | 1 | |a Amaral Leonard |e aut |
| 700 | 0 | 1 | |a Molnár József |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10441/1/2583773_AR.pdf |z Dokumentum-elérés |