Familial multiple sclerosis case study of three affected siblings /
We report on three sisters with new-onset multiple sclerosis (MS). The symptoms of the eldest sister began in 1993 with lower-limb weakness and paraesthesia. In 1998, she had limb weakness, nystagmus and ataxia. Magnetic resonance imaging (MRI) of the brain, the cerebrospinal fluid (CSF) examination...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2002
|
| Sorozat: | ACTA NEUROLOGICA SCANDINAVICA
106 No. 6 |
| doi: | 10.1034/j.1600-0404.2002.01348.x |
| mtmt: | 1032225 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10274 |
| LEADER | 01981nab a2200289 i 4500 | ||
|---|---|---|---|
| 001 | publ10274 | ||
| 005 | 20190522141657.0 | ||
| 008 | 170117s2002 hu o 0|| zxx d | ||
| 022 | |a 0001-6314 | ||
| 024 | 7 | |a 10.1034/j.1600-0404.2002.01348.x |2 doi | |
| 024 | 7 | |a 1032225 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Bencsik Krisztina | |
| 245 | 1 | 0 | |a Familial multiple sclerosis |h [elektronikus dokumentum] : |b case study of three affected siblings / |c Bencsik Krisztina |
| 260 | |c 2002 | ||
| 300 | |a 392-395 | ||
| 490 | 0 | |a ACTA NEUROLOGICA SCANDINAVICA |v 106 No. 6 | |
| 520 | 3 | |a We report on three sisters with new-onset multiple sclerosis (MS). The symptoms of the eldest sister began in 1993 with lower-limb weakness and paraesthesia. In 1998, she had limb weakness, nystagmus and ataxia. Magnetic resonance imaging (MRI) of the brain, the cerebrospinal fluid (CSF) examinations, and evoked potentials verified MS. The middle sister exhibited left-side optic neuritis in 1998. All findings pointed to MS. The third sister had subjective complaints such as paraesthesias and vertigo. MRI and CSF results supported the diagnosis. Both parents and all four grandparents are without neurological signs; the brain MRI examinations on the parents were negative. The prevalence of familial MS in first-degree relatives is 5-10%, while that in twins is 20-30%. In this case, environmental factors seem to play the crucial role. Although the anamnesis as concerns MS proved negative in the other family members examined here, further genetic examination of the sisters is needed. | |
| 700 | 0 | 1 | |a Rajda Cecilia |e aut |
| 700 | 0 | 1 | |a Seres Erika |e aut |
| 700 | 0 | 1 | |a Vörös Erika |e aut |
| 700 | 0 | 1 | |a Janáky Márta |e aut |
| 700 | 0 | 1 | |a Dibó György |e aut |
| 700 | 0 | 1 | |a Járdánházy Tamás |e aut |
| 700 | 0 | 1 | |a Vécsei László |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10274/1/Bencsik_et_al_2002_Acta_Neurologica_Scandinavica_u.pdf |z Dokumentum-elérés |