COX-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus
Objective.-The aim of the present study was to determine which isoform of the cyclooxygenase (COX) enzyme plays a role in the neuronal nitric oxide synthase (nNOS) activation caused by nitroglycerin (NTG), in the most caudal part of the trigeminal caudal nucleus (TNC) of the rat. Background.-Nitric...
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| Format: | Article |
| Published: |
2007
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| Series: | HEADACHE
47 No. 9 |
| doi: | 10.1111/j.1526-4610.2006.00721.x |
| mtmt: | 1117025 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10006 |
| LEADER | 02493nab a2200289 i 4500 | ||
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| 001 | publ10006 | ||
| 005 | 20190313114342.0 | ||
| 008 | 161124s2007 hu o 0|| zxx d | ||
| 022 | |a 0017-8748 | ||
| 024 | 7 | |a 10.1111/j.1526-4610.2006.00721.x |2 doi | |
| 024 | 7 | |a 1117025 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Varga Hedvig | |
| 245 | 1 | 0 | |a COX-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus |h [elektronikus dokumentum] / |c Varga Hedvig |
| 260 | |c 2007 | ||
| 300 | |a 1319-1325 | ||
| 490 | 0 | |a HEADACHE |v 47 No. 9 | |
| 520 | 3 | |a Objective.-The aim of the present study was to determine which isoform of the cyclooxygenase (COX) enzyme plays a role in the neuronal nitric oxide synthase (nNOS) activation caused by nitroglycerin (NTG), in the most caudal part of the trigeminal caudal nucleus (TNC) of the rat. Background.-Nitric oxide donor, NTG, can trigger migraine attack in migraineurs, but not in healthy persons. In rats, subcutaneous administration of NTG (10 mg/kg) increases significantly the number of nNOS-immunoreactive neurons in the TNC after 4 hours, which could be attenuated by acetyl-salicylate (Aspirin), a nonselective COX-inhibitor. Methods.-SPRD rats were divided into 3 groups: (1) control group (no drug administration), (2) NS398 (selective COX-2 inhibitor) administration (1, 3, or 5 mg/kg), and (3) SC560 (selective COX-1 inhibitor) administration (1, 5, or 10 mg/kg). Thirty minutes after drug administration, the animals received NTG (10 mg/kg) or placebo injection. Four hours later the animals were transcardially perfused and the cervical part of the TNC was removed for immunohistochemistry. Results.-The selective COX-2 inhibitor NS398 in contrast to the selective COX-1 inhibitor SC560 attenuates the NTG-induced nNOS expression dose-dependently. Conclusion.-These findings suggest that metabolites deriving from COX-2 (but not COX-1) may be the most important factors in the NTG-induced nNOS expression. These data could help to better understand the pathogenesis of headaches and the action of antimigraine drugs. | |
| 700 | 0 | 1 | |a Párdutz Árpád |e aut |
| 700 | 0 | 1 | |a Vámos Enikő |e aut |
| 700 | 0 | 1 | |a Plangár Imola |e aut |
| 700 | 0 | 1 | |a Együd Eszter |e aut |
| 700 | 0 | 1 | |a Tajti János |e aut |
| 700 | 0 | 1 | |a Bari Ferenc |e aut |
| 700 | 0 | 1 | |a Vécsei László |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10006/1/Varga_et_al_2007_Headache__The_Journal_of_Head_and_Face_Pain_u.pdf |z Dokumentum-elérés |