New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives
The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for thei...
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| Dokumentumtípus: | Disszertáció |
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2022-08-24
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| Tárgyszavak: | |
| doi: | 10.14232/phd.11328 |
| mtmt: | 34118001 |
| Online Access: | http://doktori.ek.szte.hu/11328 |
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| 024 | 7 | |a 10.14232/phd.11328 |2 doi | |
| 024 | 7 | |a 34118001 |2 mtmt | |
| 040 | |a SZTE Doktori Repozitórium |b hun | ||
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| 100 | 1 | |a Shahmohammadi Sayeh | |
| 245 | 1 | 0 | |a New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives |h [elektronikus dokumentum] / |c Shahmohammadi Sayeh |
| 260 | |c 2022-08-24 | ||
| 502 | |a Disszertacio | ||
| 520 | 3 | |a The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino esters (R)-4a–e. The second objective of my work was a comparative investigation of different green strategies and then to build an environmentally benign CALB-catalyzed hydrolysis of cis carbocyclic amino esters 6–9. | |
| 650 | 4 | |a gyógyszerészeti tudományok | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Szerves kémia | |
| 650 | 4 | |a Orvos- és egészségtudomány | |
| 700 | 0 | 1 | |a Forró Enikő |e ths |
| 700 | 0 | 1 | |a Fülöp Ferenc |e ths |
| 856 | 4 | 0 | |u https://doktori.bibl.u-szeged.hu/id/eprint/11328/2/Thesis-Sayeh_2022-27-may.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u https://doktori.bibl.u-szeged.hu/id/eprint/11328/1/brief%20thesis%20Sayeh%20Shahmohammadi.pdf |z Dokumentum-elérés |