Investigation of the antiremodeling effects of losartan, mirabegron and their combination on the development of doxorubicin-induced chronic cardiotoxicity in a rat model
Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development of chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling of various etiologies. The beta-3 adrenergic receptor ag...
Elmentve itt :
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| További közreműködők: | |
| Dokumentumtípus: | Disszertáció |
| Megjelent: |
2022-05-16
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| Kulcsszavak: | onco-cardiology; doxorubicin-induced chronic cardiotoxicity; heart failure; cardiac fibrosis; diastolic dysfunction; angiotensin II receptor blocker; beta-3 adrenoceptor agonist; cardiac inflammation; TGF-β/SMAD signaling pathway; sarcoendoplasmic reticulum calcium ATPase 2a |
| Tárgyszavak: | |
| doi: | 10.14232/phd.11246 |
| mtmt: | 33094425 |
| Online Access: | http://doktori.ek.szte.hu/11246 |