Drug-induced and transgenic LQTS rabbit models with reduced repolarization reserve to study proarrhythmic drug effects
Proarrhythmia - the triggering of arrhythmias following drug therapy - is a rare, but potentially lethal side-effect of various drugs, and therefore, a major safety concern during drug development. Most often proarrhythmia is caused by the drugs’ potential to interact with various K+-channels in the...
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| További közreműködők: | |
| Dokumentumtípus: | Disszertáció |
| Megjelent: |
2021-03-23
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| Kulcsszavak: | proarrhythmia, transgenic long QT rabbit model, potassium channel blocker, Torsades de Pointes |
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| doi: | 10.14232/phd.10811 |
| mtmt: | 32480179 |
| Online Access: | http://doktori.ek.szte.hu/10811 |