Comparative biochemical and pharmacological investigations of various newly developed opioid receptor ligands
Bentley analogues: In vitro competition binding experiments all derivatives showed low subnanomolar affinity to MOR. For DOR the ligands showed comparable binding affinities than the selective DOR agonist Ile5,6-deltorphin II peptide ligand except 8 (Ki > 3000 nM). In the KOR binding assays the a...
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| Format: | Dissertation |
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2021-02-04
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| Kulcsszavak: | Opiod receptors, kynurenines, efficacy, binding affinity, inflammatory pain model, Bentley analogues, oligopeptides |
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| doi: | 10.14232/phd.10631 |
| mtmt: | 32475872 |
| Online Access: | http://doktori.ek.szte.hu/10631 |