Betti bases as chiral ligands in the environmentally benign enantioselective transfer hydrogenation
There is a great need for enantioselective synthesis of biological active compounds, since in many cases only one of the stereoisomers can be used as pharmaceutical. Enantioselective transfer hydrogenations of ketones usually catalysed by metal complexes formed with bifunctional ligands, such as 1,2...
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| Corporate Author: | |
| Format: | Book part |
| Published: |
University of Szeged
Szeged
2024
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| Series: | Proceedings of the International Symposium on Analytical and Environmental Problems
30 |
| Kulcsszavak: | Környezetkémia, Gyógyszerkémia |
| Subjects: | |
| Online Access: | http://acta.bibl.u-szeged.hu/85745 |
| Summary: | There is a great need for enantioselective synthesis of biological active compounds, since in many cases only one of the stereoisomers can be used as pharmaceutical. Enantioselective transfer hydrogenations of ketones usually catalysed by metal complexes formed with bifunctional ligands, such as 1,2-aminoalcohols, are convenient methods of obtaining chiral alcohols. Our aim was to apply in the enantioselective reduction of a ketone an easily obtained Betti base as chiral ligand, which have not yet been employed in these reactions. During the present study we have obtained complete conversions and high enantioselectivities, up to 96%, in an environmentally friendly aqueous solvent mixture with the simplest Betti base enantiomers prepared from benzaldehyde, ammonia and -naphthol. We hope that our results will pave the way of the application of 1,3-aminohydroxyl derivatives as chiral ligands in other asymmetric catalytic processes as well. |
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| Physical Description: | 303-307 |
| ISBN: | 978-963-688-009-5 |