Optimization of dispersive liquid-liquid microextraction for polyethylene glycol-coated gold and silver nanoparticles

The use of polyethylene glycol modified nanoparticles is becoming an interesting topic since they present a very good stability in biological media. However, the effects of these nanoparticles on organisms are still unclear, so it is necessary to monitor their presence in bodily fluids, such as plas...

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Bibliographic Details
Main Authors: Torregrosa Daniel
Grindlay Guillermo
Ungor Ditta
Csapó Edit
Galbács Gábor
Corporate Author: International Symposium on Analytical and Environmental Problems (27.) (2021) (Szeged)
Format: Book part
Published: University of Szeged Szeged 2021
Series:Proceedings of the International Symposium on Analytical and Environmental Problems 27
Kulcsszavak:Analitikai kémia
Subjects:
Online Access:http://acta.bibl.u-szeged.hu/76002
Description
Summary:The use of polyethylene glycol modified nanoparticles is becoming an interesting topic since they present a very good stability in biological media. However, the effects of these nanoparticles on organisms are still unclear, so it is necessary to monitor their presence in bodily fluids, such as plasma or urine. Single-particle ICP-MS is a versatile tool to simultaneously detect and characterize nanoparticles in aqueous media, but a previous extraction step is necessary when analyzing complex samples due to the occurrence of matrix effects. In this work, an ultrasound assisted dispersive liquid-liquid microextraction method based on the use of chloroform as extracting solvent has been optimized for the extraction, characterization, and quantification of polyethylene glycol modified gold and silver nanoparticles in aqueous media. So far, we could achieve extraction efficiencies higher than 75% for both types of nanoparticles studied. We believe that with further optimization, the extraction can be made quantitative.
Physical Description:343-347
ISBN:978-963-306-835-9