Transition metal-catalyzed synthesis of 13α-estrone derivatives with potential anticancer properties
Synthesis of 3-(N,N-dimethylcarbamoyl)-13α-estrone and its 17-deoxy counterpart has been carried out. The dimethylcarbamoyl directing group enabled the regioselective ortho arylation of the steroidal starting compounds. The microwave-assisted, palladium-catalyzed phenylations led to 2-substituted 13...
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| Dokumentumtípus: | Könyv része |
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2020
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Gyógyszerkémia, Analitikai kémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/74032 |
| Tartalmi kivonat: | Synthesis of 3-(N,N-dimethylcarbamoyl)-13α-estrone and its 17-deoxy counterpart has been carried out. The dimethylcarbamoyl directing group enabled the regioselective ortho arylation of the steroidal starting compounds. The microwave-assisted, palladium-catalyzed phenylations led to 2-substituted 13α-estrones in a one-pot, tandem process. The Suzuki-Miyaura cross coupling reactions of the carbamates with phenylboronic acid resulted in 3-phenyl-3-deoxy13α-estrone. Certain newly synthesized compounds displayed potent antiproliferative action against human reproductive cancer cell lines of gynecological origin. |
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| Terjedelem/Fizikai jellemzők: | 338-341 |
| ISBN: | 978-963-306-771-0 |