Determination of valine and leucine isomers in peptaibols
Peptaibols are oligomers, containing non-proteogenic amino acids. Some of them are considered as antifungal and antibiotic agents, therefore the elucidation of their structure is important. There have been a lot of efforts determining their amino acid sequences via mass spectrometry, but isobaric co...
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Main Authors: | |
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Corporate Author: | |
Format: | Book part |
Published: |
2018
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Series: | Proceedings of the International Symposium on Analytical and Environmental Problems
24 |
Kulcsszavak: | Gyógyszerkémia, Mikrobiológia |
Online Access: | http://acta.bibl.u-szeged.hu/56350 |
Summary: | Peptaibols are oligomers, containing non-proteogenic amino acids. Some of them are considered as antifungal and antibiotic agents, therefore the elucidation of their structure is important. There have been a lot of efforts determining their amino acid sequences via mass spectrometry, but isobaric components cannot be determined using this technique. In this work, a HPLC method development was carried out for the determination of leucine, isoleucine, valine and isovaline in one chromatographic run. Furthermore, a chiral separation of the optical isomers of these compounds has been also solved. |
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Physical Description: | 283-285 |
ISBN: | 978-963-306-623-2 |