Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron
It is assumed that the amyloid-beta peptide (Ab) contributes to the neurodegeneration in Alzheimer’s disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Ab protein may be an activator of caspase-3 and c...
Elmentve itt :
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Dokumentumtípus: | Cikk |
Megjelent: |
2004
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Sorozat: | Acta biologica Szegediensis
48 No. 1-4 |
Kulcsszavak: | Természettudomány, Biológia |
Online Access: | http://acta.bibl.u-szeged.hu/22626 |
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005 | 20210413113640.0 | ||
008 | 161017s2004 hu o 0|| eng d | ||
022 | |a 1588-385X | ||
040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
041 | |a eng | ||
100 | 1 | |a Kása Péter | |
245 | 1 | 0 | |a Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron |h [elektronikus dokumentum] / |c Kása Péter |
260 | |c 2004 | ||
300 | |a 1-6 | ||
490 | 0 | |a Acta biologica Szegediensis |v 48 No. 1-4 | |
520 | 3 | |a It is assumed that the amyloid-beta peptide (Ab) contributes to the neurodegeneration in Alzheimer’s disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Ab protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofibrillary degeneration in a postsynaptic cell. We report here that the axonic Ab in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a significant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau-protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofibrillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death associated with AD. However, we are aware that, besides Ab, other factors too may initiate a series of events which lead to the development of neurofibrillary tangles in the postsynaptic neurons. | |
695 | |a Természettudomány, Biológia | ||
856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/22626/1/481.pdf |z Dokumentum-elérés |